Peripheral Vascular Disease (PVD) is a condition that affects the circulatory system, specifically the blood vessels that are outside of the heart and brain. PVD can cause the blood vessels to narrow, making it more difficult for blood to flow through them. This can cause a range of symptoms, including pain in the legs, feet, and toes, as well as changes in skin color and temperature. PVD is often caused by a build-up of fatty deposits on the inner walls of the blood vessels, a condition known as atherosclerosis. Risk factors for PVD include smoking, diabetes, high blood pressure, and high cholesterol. Treatment for PVD may include lifestyle changes, medications, and, in severe cases, surgery.